--- title: 'Agriculture Daily Summary: What Happened on October 13, 2026' headline: Rothamsted identifies first confirmed SDHI resistance in oilseed rape pathogen description: A separate study used PrimeStack to insert large genetic cargos into rice, with efficiency reaching 45%. url: https://thebench.bio/news/agriculture/2026-10-13 topic: agriculture date: '2026-10-13' covers: - '2026-10-13' date_published: '2026-10-14T00:03:34Z' date_modified: '2026-10-14T00:03:34Z' tags: - Agriculture - Industry sources: 2 publisher: TheBench.Bio --- # Agriculture Daily Summary: What Happened on October 13, 2026 **Rothamsted identifies first confirmed SDHI resistance in oilseed rape pathogen** A separate study used PrimeStack to insert large genetic cargos into rice, with efficiency reaching 45%. ## Today in brief The first confirmed SDHI fungicide resistance in Plenodomus biglobosus was found in samples from the UK and Poland, Rothamsted Research scientists reported. [1] In rice, a gene-editing platform called PrimeStack inserted large genetic cargos at targeted sites, reaching 45% efficiency in regenerated plants. [2] ## Resistance to two fungicides found in oilseed rape pathogen Rothamsted Research scientists reported the first confirmed resistance to SDHI fungicides in Plenodomus biglobosus, an oilseed rape pathogen. [1] Laboratory tests found resistance to boscalid and fluxapyroxad in samples from the UK and Poland. [1] Resistance to both fungicides was found in 95% of UK isolates and 6% of Polish isolates tested. [1] Some UK isolates showed up to a 500-fold reduction in sensitivity. [1] Researchers linked resistance to mutations in genes encoding the enzyme targeted by SDHI fungicides. [1] The study found limited evidence that the mutations impaired the pathogen's fitness, suggesting resistant strains might persist in fields. [1] Kevin King said further work is needed to assess how resistance affects disease control in fields. [1] ## PrimeStack inserts large genetic cargos into rice Researchers combined prime editing with the Bxb1 integrase enzyme to create PrimeStack, which inserts multigene DNA cargos at targeted sites without double-strand DNA breaks. [2] In regenerated rice plants, integration efficiency reached 45%, measured by junction-specific PCR. [2] The team demonstrated the method by inserting a carotenoid cassette at an experimentally confirmed genomic safe-harbor site. [2] Under the tested conditions, plants showed no obvious morphological differences from unedited plants five weeks after transfer to soil. [2] ## Also worth knowing - Jon West said continued monitoring of both Phoma pathogens could provide early warning of fungicide resistance and help preserve fungicide effectiveness. [1] ## The day in numbers - **95%**: Share of UK Plenodomus biglobosus isolates resistant to boscalid and fluxapyroxad in laboratory testing. [1] - **45%**: Highest reported efficiency for targeted large-cargo integration in regenerated rice plants using PrimeStack. [2] ## Sources 1. [A New Phoma Threat Raises the Stakes for Oilseed Rape Breeders](), European Seed, 2026-10-13 2. [PrimeStack editors enable efficient and site-specific integration of large multigene cargos in plants](), PLOS Biology, 2026-10-13 --- TheBench.Bio wrote this from the reporting cited above, with a language model drafting and editing. [1]: [2]: