--- title: 'Manufacturing Daily Summary: What Happened on October 28, 2026' headline: Limerick researchers test a model-based route to digital validation description: The proof of concept links process understanding, controller design and validation evidence, but requires adaptation before industrial use. url: https://thebench.bio/news/manufacturing/2026-10-28 topic: manufacturing date: '2026-10-28' covers: - '2026-10-28' date_published: '2026-10-29T00:04:32Z' date_modified: '2026-10-29T00:04:32Z' tags: - Industry sources: 1 publisher: TheBench.Bio --- # Manufacturing Daily Summary: What Happened on October 28, 2026 **Limerick researchers test a model-based route to digital validation** The proof of concept links process understanding, controller design and validation evidence, but requires adaptation before industrial use. ## Today in brief A University of Limerick team demonstrated that a model-based pH controller could move from a development environment into an industrial control system. [1] ## A workflow from process model to controller Researchers at the Pharmaceutical Manufacturing Technology Center and the University of Limerick developed a risk-based workflow for validating digital pharmaceutical manufacturing systems. [1] The team built a model predictive controller for pH regulation using a data-driven Hammerstein-Wiener model, then assessed process and control risks to identify and prioritize failure modes. [1] The workflow connects process understanding, risk management, controller development, requirements, verification and deployment, allowing evidence to be generated during system development, Dermot McMorrow said. [1] The researchers demonstrated that a controller developed and verified in a model-based environment could be deployed in an industrial programmable logic controller environment. [1] McMorrow described the study as a proof of concept, not a solution ready for direct deployment. [1] Industrial use would require fitting the workflow into an organization’s quality system, validation strategy and regulatory context, he said. [1] ## Also published - [WMFTS Process Pumps in Automation](), BioProcess International - [Decentralization, AI, and Gene Editing are Opportunities for CGT Contractors](), GEN - [Collaboration and Roadmaps Key to Capsid Accessibility](), GEN - [Is the Future of Bioprocessing Too Intense?](), BioProcess International ## Sources 1. [Crossing the Digital Validation Chasm](), GEN, 2026-10-28 --- TheBench.Bio wrote this from the reporting cited above, with a language model drafting and editing. [1]: