Biotech software news summary, 10 November

Today in brief

Fable 5.2 turned a typed sentence into simulated DNA sequencing and assembly in an interactive browser demo, with examples that succeed and fail.1 An antibody-optimization agent’s developer described tests for its tool use, reasoning and ability to follow workflows.2

A prompt becomes a sequencing demo

The author used Fable 5.2 to build an interactive browser demo that converts a sentence into DNA, simulates short reads with errors and assembles them in two ways.1 One assembly attempt uses mate information, and the demo shows both successful and visibly failed examples.1 The author says a single prompt, with no follow-up, produced the demo in about 15 minutes.1

How to test an antibody-optimization agent

The agent is intended to use computational tools to find antibody developability problems, suggest changes and assess the resulting candidates, its author says.2 The author recommends testing tool execution and choice, scientific interpretation and multi-step workflows.2 Generated sequences cannot all be tested experimentally, and computational improvements may not indicate biological validity, the author cautions.2 The project uses a defined workflow to check whether the agent follows it, with smaller tasks making evaluation and debugging easier.2

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